Amazon Studios has dropped the full Dead Ringers trailer for the upcoming limited drama, based on David Cronenberg’s 1988 cult classic of the same name. The remake will be available for streaming on April 21.

The video features Rachel Weisz in the dual role of twin gynecologists Elliot and Beverly Mantle as they try to change the world by pushing the boundaries in women’s health care. It also highlights their complicated relationship, as well as the brilliance and madness that they bring out of each other.

You can check out the Dead Ringers trailer below:

Prime Video’s Dead Ringers is described as a modern take on Cronenberg’s cult classic movie. Joining Weisz in the six-episode drama are Britne Oldford (The Umbrella Academy) as Genevieve, Poppy Liu (Better Call Saul) as Greta, Michael Chernus (Severance) as Tom, Jennifer Ehle (Zero Dark Thirty) as Rebecca, and Emily Meade (The Deuce) as Susan.

“The series follows Elliot and Beverly Mantle, twin gynecologists who share everything: drugs, lovers, and an unapologetic desire to do whatever it takes — including pushing the boundaries of medical ethics — in an effort to challenge antiquated practices and bring women’s health care to the forefront,” reads the synopsis.

Dead Ringers is created, written, and executive produced by Alice Birch (Normal People), who is also set as the showrunner. Executive producers are Weisz, Stacy O’Neil, Sue Naegle, Sean Durkin, Ali Krug, Erica Kay, Anne Carey, Polly Stokes, James G. Robinson, David Robinson, and Barbara Wall. It hails from Amazon Studios and Annapurna Television.